So we postulated that the miR-335 genes undergo epigenetic inactivation in GC. In this study, we find the promoter of miR-335 we embedded in CpG island by accessing to bioinformatics data and the low expression of miR-335 in 5 gastric cell lines can be restored by 5-aza-2’-deoxycytidine (5-Aza-dC) treatment. Recent studies have shown that the silencing of some miRNAs is associated with DNA hypermethylation. However, the mechanisms which result in aberrant expression of miR-335 in GC are still unknown. MicroRNAs (miRNAs) are small non-coding RNAs that function as endogenous silencers of target genes, previous studies have shown that miR-335 play an important role in suppressing metastasis and migration in human cancer including gastric cancer (GC).
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